Pryor got the Raiders (2-3) off to a fast start in the latest starting West Coast game in NFL history with a 44-yard touchdown pass on Oakland's first play from scrimmage.
Philip Rivers had his third 400-yard passing game of the season, throwing for 411 yards and two touchdowns. But he also had three interceptions as the Chargers played without injured starting offensive linemen King Dunlap and Chad Rinehart. They also lost running back Ryan Mathews to a concussion in the first half.
The game was shifted to a late-night start to allow time to convert the Coliseum to its football configuration after the Oakland Athletics played a baseball playoff game here Saturday night. The process took about 18 hours and was completed around 3:30 p.m., more than five hours before kickoff at 8:35 p.m.
The wait was more than worth it for Oakland fans who had plenty to cheer about right from the start as Pryor and the Raiders broke out to a 17-0 halftime lead.
The Chargers' first score didn't come easily as Nick Novak had a 37-yard field goal attempt blocked by Tracy Porter. But Ladarius Green picked up the ball behind the line of scrimmage and ran for a first down. Rivers appeared to throw a touchdown pass to Keenan Allen two plays later but the call was reversed after replay showed Allen got only one foot down inbounds.
That led to a second field goal attempt for Novak and he connected this time from 35 yards to cut Oakland's lead to 17-3.
The Raiders appeared to break the game open when Woodson scooped up Woodhead's fumble and ran it in to make it 24-3. That tied him with Darren Sharper and Rod Woodson for the most defensive touchdowns in NFL history.
But Rivers and the Chargers didn't quit, scoring touchdowns on their next two drives on passes to Woodhead and Allen in the opening 5 minutes of the fourth quarter to cut the deficit to 24-17.
Pryor came up with one more big play, scrambling before hitting Brice Butler on a 20-yard pass on third-and-14. That set up Janikowski's 50-yard field goal that made it 27-17. Pryor finished 18 of 23 for 223 yards.
Oakland rookie D.J. Hayden and Woodson added late interceptions to seal the win.