Built in the 1990s, the west-facing property sits on almost half an acre and overlooks Stone Canyon Reservoir and Bel-Air.
The main house features an open-plan living and dining room, a den, four bedrooms and 31/2 bathrooms. The recently renovated guesthouse contains another bedroom and 11/2 bathrooms. Outdoors is a pool, a spa and a dining pavilion.
Pattinson, 25, and Stewart, 21, have starred in the "Twilight Saga" series of films since the original "Twilight" vampire film in 2008. "The Twilight Saga: Breaking Dawn — Part 1" was released last month, and Part 2 is set for next year.
David Mossler of Teles Properties, Beverly Hills, is the listing agent.