"Jay Leno and Friends" is scheduled for May 23 and will feature Leno as well as other performers, including comedienne Kathy Buckley, who will host the event.
The benefit will raise funds for No Limits, a nonprofit organization that supports theater and education initiatives for deaf children, as well as the Geffen's education and outreach programs.
Tickets range between $75 and $125, and VIP packages are also available. The VIP packages include a pre-show dinner and post-show reception.
"Jay Leno and Friends" will also include an appearance by Fritz Coleman, the longtime Los Angeles weathercaster.
Leno is the former host of NBC's "The Tonight Show." Since stepping down last year, the comedian and car collector has performed stand-up shows and benefits around the country.
The May 23 performance will be part of the Geffen's Spotlight Entertainment Series, which brings noted screen and theater entertainers to the Westwood company.