Naturally, the emotional fallout from that plot was one of several focal points in "Parenthood's" fifth season, which we'll discuss with Potter when she stops by our studio on Thursday at 2:30 p.m. PDT.
Potter's character, Kristina Braverman, recovered enough this year to run for mayor, a story that the actress calls harder to pull off than the cancer arc because the character's trepidation was almost contagious.
Kristina also had to deal with the loss of a close friend to cancer and cope with survivor's guilt afterward.
"I can be a friend and a sister and a daughter, but she can’t," Kristina cried to her husband, Adam. "Why do I get to be lucky, and she doesn't? It’s not right, and I'm mad. I'm mad!"
Potter pulled off the scene with customary grace and relatability, the kind of talent that earned her a Golden Globe nomination and Critics Choice Television Award last year for her work on the show.
We'll talk to Potter about the rewards and challenges of "Parenthood," as well as anything you'd like to ask. Leave your questions in the comments section of this story or tweet them to #asklatimes, and we'll pass them along.