Patrick Dempsey's wife, Jillian Fink, has filed for divorce from the actor made famous as "McDreamy" on "Grey's Anatomy."
Dempsey and Fink made the decision to split "with careful consideration and mutual respect" and are focused on their kids' well-being, his rep said in a statement to several outlets.
TMZ, which first reported the filing Friday, said the two don't have a prenuptial agreement to guide them through parceling out an estimated $40 million brought in during their union.
The couple tied the knot in July 1999, six years before "Grey's" would launch its successful run on TV. It was the actor's second marriage.
Dempsey, 49, and Fink, a makeup artist, have three kids together: 12-year-old Tallulah Fyfe and 7-year-old twins Sullivan and Darby.