They led by as many as 37 points in their fifth consecutive game without Blake Griffin, who is sidelined after having surgery Feb. 9 to remove a staph infection in his right elbow.
The Clippers outscored the Kings, 42-18, in the second quarter and, 31-18, in the third quarter.
Five Clippers finished in double figures, including two reserves.
Austin Rivers, who missed Thursday's game because of a sore left ankle, had a career-high 28 points on 11-for-19 shooting off the bench. He made five of his nine three-point shots.
Jamal Crawford added 23 points off the bench on 10-for-18 shooting.
J.J. Redick had 24 points, making four of his six three-point attempts. DeAndre Jordan, who has been stellar in the month of Februrary by averaging 17 points on 70% shooting and 16.6 rebounds, finished with 11 points and 15 boards.
Jordan, who had shot 54 free throws in the team's last two games before Saturday, only went to the free-throw line twice, making one of the shots, against the Kings.
The Clippers outshot the Kings from the field, 48.4% to 34.1%, and from beyond the three-point line, 40% to 25%.
The Clippers (37-19) are in fifth place in the Western Conference, while the Kings (19-35) are in 13th place.
The Clippers host the Memphis Grizzlies on Monday before leaving for a four-game trip, extending from Feb. 25-March 2.