They took their biggest lead of the game in the fourth quarter at 21 points, and went on to outshoot the Timberwolves from the field, 44.3% to 37.3%, and from beyond the three-point line, 35.5% to 25%.
Blake Griffin (right elbow) and Jamal Crawford (right calf bruise) missed Monday's game.
The Timberwolves were without
The Clippers are in fifth place in the Western Conference with a record of 41-23, while the Timberwolves are in last place with a record of 14-48.
The Timberwolves were trying to put together just their second win streak of the season, after beating Portland on Saturday.
Adreian Payne led the Timberwolves with 16 points and 15 rebounds. The next highest scorer for Minnesota was