The Clippers were playing without star power forward Blake Griffin, who will have surgery Monday to remove a staph infection in his right elbow. The Clippers will have a better idea of Griffin’s timetable after his surgery, but he's expected to miss between 10 days to six weeks.
The Clippers trailed the Thunder by as many as 32 points, and were outrebounded, 54-29.
Clippers reserve power forward Spencer Hawes started in Griffin's place. Hawes tied his season-high with 17 points on 7-for-16 shooting, but he had just one rebound. Jamal Crawford led the Clippers with 21 points and Chris Paul had 18 points and 13 assists.
J.J. Redick was sidelined for the second consecutive game with back spasms. The team also lost Glen Davis in the first half to upper back spasms.
The Clippers were oushot from the field, 52.3% to 46.7%.
Kevin Durant led the Thunder with 29 points on 10-for-15 shooting, five rebounds and six assists.
The loss dropped the Clippers to seventh in the Western Conference with a record of 33-19. The Thunder, who are 10th in the West, improved to 26-25.
It was the Clippers' first time playing at Oklahoma City since their Game 5 collapse in their Western Conference semifinal series last season, when the Clippers gave up a seven-point lead with 49 seconds left.
The Clippers, who are 2-5 on their eight-game trip, will play at Dallas on Monday to conclude what has been an arduous stretch.