James donned a dark mask to protect his broken nose and was clearly unencumbered, hitting 13 of 19 shots and topping 30 points for the fifth consecutive game.
Wade shot 10 for 13 from the field for Miami, which outscored New York, 23-3, over the final 7:02 of the third and won its sixth straight.
The Heat shot 61%, while the Knicks shot 37%.
The Heat are 41-7 in February games over the last four seasons.
Washington 134, at Toronto 129 (3OT): The Wizards' Trevor Ariza scored the go-ahead basket on a fastbreak layup with 1:20 left in the third overtime. Marcin Gortat fouled out with 31 points and 12 rebounds, John Wall also had 31 points, and Ariza fouled out with 16 points and 10 rebounds for the Wizards, who won their fifth straight and improved to 2-0 since losing Nene to a knee injury. DeMar DeRozan scored 34 points in 58 minutes for the Raptors.
Brooklyn 112, at Denver 89: Paul Pierce scored 18 points as the Nets rebounded from their worst loss in 11 years. Randy Foye had 15 points to lead the Nuggets, who have lost four in a row and nine of 10.
at Indiana 101, Milwaukee 96: Roy Hibbert had 24 points and 12 rebounds to help the Pacers rally. Indiana, an NBA-leading 44-13 overall and an NBA-best 28-3 at home, blew a 17-point lead in the first half. Indiana starting guard George Hill took a nasty spill along the baseline late in the game. He was favoring his left shoulder as he walked off the court. Hill had nine points.