James donned a dark mask to protect his broken nose and was clearly unencumbered, hitting 13 of 19 shots and topping 30 points for the fifth consecutive game.
Wade shot 10 for 13 from the field for Miami, which outscored New York, 23-3, over the final 7:02 of the third and won its sixth straight.
The Heat shot 61%, while the Knicks shot 37%.
The Heat are 41-7 in February games over the last four seasons.
Washington 134, at Toronto 129 (3OT): The
Brooklyn 112, at Denver 89: