The unbeaten Fighting Irish (34-0) have won their last 15 games by double digits, though the Sun Devils (23-10) kept this one close during a sloppy first half. Deja Mann scored 16 points for Arizona State.
Kayla McBride had 22 points for Notre Dame.
In other games in the Notre Dame Regional:
Oklahoma State 73, Purdue 66: Brittney Martin had 20 points and 20 rebounds to lead Oklahoma State at West Lafayette, Ind.
The Cowgirls (25-8) won their second straight, ending a 15-game stretch in which they had alternated wins and losses.
Fourth-seeded Purdue (22-9) was led by Whitney Bays with 21 points.
Baylor 75, California 56: Odyssey Sims scored 27 points in her final home game and Baylor (31-4) advanced to its sixth consecutive regional semifinals at Waco, Texas.
Afure Jemerigbe had 17 points for Cal (22-10).
Kentucky 64, Syracuse 59: Bria Goss scored 17 points to lead the Wildcats at Lexington, Ky.
Goss shot 11 for 12 from the foul line as the Wildcats (26-8) ground out a victory two days after beating Wright State by 46 points.
Syracuse finished 23-10.
Stanford 63, Florida State 44: Chiney Ogwumike had 19 points and nine rebounds to lead the Cardinal (31-3) at Ames, Iowa, in the Stanford Regional.
The 10th-seeded Seminoles (21-12) struggled to score in both of their tournament games.
Tennessee 67, St. John's 51: Cierra Burdick had 21 points and 11 rebounds as the Lady Vols relied on their smothering defense to pull away at Knoxville, Tenn., in the Louisville Regional. The Red Storm (23-11) never led.
DePaul 74, Duke 65: Megan Rogowski scored 22 points to help the Blue Demons (29-6) pull the upset at Durham, N.C., in the Lincoln Regional. Duke (28-7) led for only 12 seconds and became the first top-four seed to lose in the tournament.
Brigham Young 80, Nebraska 76: Morgan Bailey tied her career high with 18 points and BYU (28-6) held on at Pauley Pavilion. Nebraska (26-7) now hosts a regional it won't be playing in.