Brandon Ashley matched his career high with 21 points, T.J. McConnell tied his career best with 11 assists and No. 5
It was the most one-sided victory for Arizona and most lopsided loss for Cal this season.
The Wildcats (27-3, 15-2) already had clinched at least a tie for the conference title and the No. 1 seed in next week's tournament. They are the first Arizona team in 21 years to repeat as conference regular-season champions.
Tyrone Wallace scored 16 points for the Bears (17-13, 7-10).