Bryant, struggling through fatigue, sat out Tuesday night when the Lakers took on the Golden State Warriors (23-4).
In a well-rounded team effort, all 10 Lakers scored, led by Carlos Boozer off the bench with 18 points and nine rebounds.
Even former Lakers center Vlade Divac hit a big shot, all the way from half court during a break in the game, winning $90,000 for charity.
As a team, the Lakers converted 51.7% from the field and 46.2% from three-point range (12-26).
Golden State's bench did their best to close the gap in the fourth quarter, holding the Lakers scoreless for almost 5 1/2 minutes, but the 24-point deficit was too much to overcome.
The Lakers (9-19) will travel to Chicago to play the Bulls (19-9) on Christmas Day. The Warriors also play on Christmas, visiting the Clippers (19-10) at Staples Center.
Stephen Curry started to do what Stephen Curry does, scoring seven points in a 50-second stretch and nine straight for his team.
The Lakers' 21-point lead was quickly shrunk to 10, but just when it looked like the Warriors were primed to overtake the Lakers, Ronnie Price converted a trio of three-pointers in a minute and a half.
When the dust settled, the Lakers were up by 22 points.
Curry scored 22 points, as the Warriors shot 42.2% and 44.4%, respectively.
The Lakers extended their lead in the second quarter to 15, giving the Warriors a surprisingly difficult time.
As a team, the Lakers shot 56.3% from the field with 19 assists. Golden State shot 40.0% with just seven assists.
Defensively, the Lakers had nine steal's to the Warriors' four, and a 5-2 advantage on blocks.
Lakers 34 - Warriors 24 (end of first quarter)
Wayne Ellington, starting in Bryant's place, didn't score -- but the Lakers as a team shot 60.9% from the field, led by Wesley Johnson with seven points.
Nick Young added six off the bench, as eight different Lakers scored.
The Warriors were led by Stephen Curry with seven points. Golden State shot 43.5% from the field.
The Lakers (8-19) have lost three-straight games.
The Warriors are down Andrew Bogut (knee).
For an in-depth breakdown, check out Preview: Lakers vs. Golden State Warriors.