Kawhi Leonard had 20 points and Aron Baynes added 18 points in 19 minutes for San Antonio, which has won six straight.
Danilo Galinari scored 20 points to lead Denver and
The Spurs (50-26) extended their league record of consecutive 50-win seasons to 16 straight. San Antonio moved into a tie with the Clippers for fifth in the Western Conference.
But Splitter's calf injury could be trouble for the Spurs, who struggled without the low-post scoring and fluid passing the starting center provides. They were 14-7 when Splitter missed over a month earlier in the season because of an injured right calf. Splitter's return to the starting lineup sparked the team's current run of 16 wins in 19 games.
Splitter exited with 5:33 remaining in the first quarter, departing immediately for the locker room with the team's trainer. His status was uncertain.
at Brooklyn 114, Toronto 109:
at Memphis 100, Oklahoma City 92:
New Orleans 101, at Sacramento 95:
Milwaukee 110, at Boston 101:
at Indiana 93, Charlotte 74:
at Chicago 88, Detroit 82:
Orlando 97, at Minnesota 84: