The Clippers entered Sunday's game having won five of their last six games, including the previous four games by an average of 25.5 points.
But against the Heat, they looked tired and out of sorts, blowing a 13-point first-quarter lead to trail by as many as 15 points.
The Heat destroyed the Clippers on the boards, 46-27. DeAndre Jordan, who is averaging a league-leading 13.7 rebounds this season, finished with only six on Sunday. In fact, Miami's Hassan Whiteside finished with 16 rebounds, more than Jordan and Blake Griffin combined (12).
Miami was just better in all facets of the game. It shared the ball, finishing with 28 assists compared to the Clippers' 17, and outshot the Clippers from the field, 48.1% to 45.3%.
Griffin led the Clippers with 26 points on 10-for-19 shooting. Chris Paul had 23 points and nine assists, and J.J. Redick added 14 points.
The Heat's bench outscored the Clippers' reserves, 37-15. Jamal Crawford, who is averaging 15.9 points off the bench this season, scored only four points on one-for-nine shooting.
The Clippers (25-13) lost to the Heat (16-21) in their second leg of back-to-back games after beating the Dallas Mavericks, 120-100, on Saturday. When the teams played in Miami on Nov. 20, the Clippers won, 110-93.
The Clippers next game is at Portland against the Trail Blazers on Wednesday.