Former Trojans defensive lineman Fili Moala is on the Colts' injured reserve list.
Holmes played for the Trojans from 2008 to 2012. He was a fourth-round pick in the 2013 NFL draft.
Pagano was a graduate assistant in 1984 and 1985.
Moala played at USC from 2005 to 2008. He was a second-round pick in 2009.
The Patriots defeated the Colts, 42-20, in Week 11 at Lucas Oil Stadium in Indianapolis.
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