Denver quarterback Brock Osweiler ran for one touchdown and threw for two more Thursday night to lead the Broncos past Indianapolis 25-13.
Osweiler replaced the injured Trevor Siemian in the first quarter and played his best football of the season.
The Broncos (5-10) needed it. After ending an eight-game losing streak Sunday, they picked up their first road win since Dec. 4, 2016.
For Indianapolis (3-11), it was more of the same. The Colts blew an early 10-0 lead and have now lost five in a row, the longest skid of coach Chuck Pagano’s six-year tenure.
Osweiler looked more like the player Denver envisioned when it drafted him in the second round in 2012, and the guy who filled in for an injured Peyton Manning during the Broncos’ 2015 Super Bowl season.
He was 12 of 17 with 194 yards and took the Broncos on three second-half scoring drives — giving the league’s top-rated defense more than enough points.
C.J. Anderson ran 30 times for a season high 158 yards.
But it was a rugged night.
Siemian went to the locker room with an injured left shoulder after Barkevious Mingo drove him into the ground on the Broncos’ second series. Siemian did not return and the Broncos had no other immediate details on the injury.
The scariest moment came with 14:01 left in the second quarter when Denver linebacker Deiontrez Mount appeared to make helmet-to-helmet contact with Colts tight end Brandon Williams on a punt. Williams was knocked over backward and stayed on the ground as players from both teams dropped to their knees while trainers and doctors strapped him to a backboard and removed his facemask.
When he was lifted onto a golf cart, Williams’ teammates came over to offer support. Colts officials said Williams had movement in his extremities and had suffered a head injury. He also did not return.
Otherwise, the game between two non-playoff teams went pretty much as expected.
After Colts quarterback Jacoby Brissett scored on a 7-yard run and Adam Vinatieri made it 10-0 with a 45-yard field goal midway through the second quarter, all Indy could muster was a 39-yard field goal early in the third.
Osweiler, meanwhile, got the Broncos in sync.
He capped a 75-yard drive with an 18-yard TD run to make it 10-7 at halftime, then gave Denver the lead with a 22-yard TD pass to Cody Latimer 4:16 left in the third quarter. Osweiler added a 54-yard TD pass to Jeff Heuerman and a 2-point conversion pass to Latimer to make 22-13 and Brandon McManus sealed the victory with a 40-yard field goal.