Following weeks of rumors,
The multitasking actor -- who lately has been devoting himself to directing, writing, the visual arts and a recent
Franco will play the role of George and O'Dowd will play his lumbering, mentally disabled friend Lennie -- two migrant laborers looking for work during the Great Depression. The play, which John Steinbeck adapted from his own novella, is a favorite among regional theaters and was last seen on Broadway in 1975, with
Anna D. Shapiro, who won a
"Of Mice and Men" will mark Franco's Broadway debut. The official opening date for the run is April 16.