The last time Obama appeared on the late-night show, which is filmed in Hollywood, was in 2008 when he was running for president.
Because of the visit, Hollywood Boulevard and Hawthorn Avenue in Hollywood will be closed to traffic in all directions from about 4:30 p.m. until just before 6 p.m. Thursday.
During the afternoon and early evening, several other streets will be closed, including an eight-minute-long closure of Sepulveda Boulevard near Los Angeles International Airport some time between 3:30 p.m. and 4:30 p.m.
After 3:30 p.m., motorists are advised to avoid Hollywood Way near Bob Hope International Airport.
Obama will be driving through Burbank between 4 p.m. and 5:30 p.m., so police have asked people to avoid driving in the area or risk being stuck in traffic jams. They plan to close San Fernando Boulevard, Cohasset Street and Thorton, Burton and Tulare avenues.
Starting at 4 p.m., drivers should avoid Highland Avenue between the Hollywood Bowl and Sunset Boulevard as well as Ocean Avenue and San Vicente Boulevard in Santa Monica.
Also in Santa Monica, 19th and 20th streets between Marguerita and Carlyle avenues will be closed until 7:30 p.m.
About one-and-a-half southbound lanes on Avenue of the Stars after Galaxy Way also will be closed.
As part of his visit to Los Angeles on Thursday, Obama also will attend a roundtable discussion hosted by ICM Partners co-founder Chris Silbermann and his wife, Julia Franz. Attendance costs $33,400 per couple.
Donations from the event will fund election operations for the Democratic National Committee.
In February, Obama traveled to San Francisco for a DNC fundraiser and played golf with friends in Palm Springs.
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