London Perrantes scored 18 points and No. 12 Virginia used a 22-5 run to begin the second half and beat fourth-ranked but short-handed
Isaiah Wilkins added 13 points, 11 rebounds and five blocks for the Cavaliers (18-5, 8-3
Freshman V.J. King scored a career-high 24 points for the Cardinals (19-5, 7-4), whose three-game winning streak was snapped.
Louisville was without its second- and third-leading scorers, with guard Quentin Snider (12.1 points per game) out because of a hip flexor and forward Deng Adel (11.1) and center Mangok Mathiang (7.1 points per game, 6.2 rebounds per game) suspended for missing curfew Saturday. Reserve guard Tony Hicks also missed the game because of a broken bone in his hand.
Louisville led 34-32 at the half but a three-pointer by Perrantes got Virginia going on the big run to open a 54-39 lead.
After losing at California on Friday night, UCLA bounced back to beat the Cardinal one game after Hall of Fame Stanford Coach Tara VanDerveer became just the second women's coach with 1,000 wins, alongside the late Pat Summitt.
Kari Korver had 17 points for UCLA (18-5, 9-3 Pac-12 Conference), while Karlie Samuelson scored 15 points and Erica McCall and Alanna Smith each added 14 for Stanford (20-4, 10-2).
UCLA forced 11 turnovers and held a 41-38 edge on the boards. Stanford shot four for 20 in the third quarter.