Kaleena Mosqueda-Lewis had the third triple-double in
Mosqueda-Lewis had 20 points, 10 rebounds and 10 assists, to lead five players in double figures for the top-ranked Huskies (36-0), who won their 42nd straight game.
Breanna Stewart added 21 points and 11 rebounds, and Bria Hartley also chipped in 20 points for the defending national champions, who are trying to win a record ninth NCAA tournament. Mosqueda-Lewis made eight of her 14 shots, three of five from three-point range.
Erin Shields and Sarah Fairbanks each had 12 points to lead St. Joseph's (23-10).
Connecticut will face 12th-seeded Brigham Young on Saturday in the regional semifinal at Lincoln, Neb. The Cougars upset