"Proud to announce that I'm committed to the University of Southern California Trojans. #FightOn," Angeline wrote on Twitter, accompanied by a photo in the Coliseum with tight ends coach Marques Tuiasosopo.
Angeline made an unofficial visit to USC in April.
The 6-foot-7, 230-pound Angeline caught 67 passes for 1,031 yards and 10 touchdowns during the 2014 season at Downington East in Exton, Penn.
Angeline, who has more than 30 offers, is the first tight end to commit to USC's 2016 recruiting class.
Here is a look at USC's 2016 commitments:
Player, position, high school
Matt Fink, QB, Glendora
Velus Jones, WR, Saraland (Ala.)
Josh Imatorbhebhe, WR, Suwanee (Ga.) North Gwinnett
Melquise Stovall, RB, Lancaster Paraclete
Frank Martin, OL, Santa Ana Mater Dei
Nathan Smith, OL, Mesa
Keanu Saleapaga, DL, La Mirada
Liam Jimmons, DL, Huntington Beach
Daelin Hayes, LB, Ann Arbor (Michigan) Skyline
Mique Juarez, LB, North Torrance
Jordan Iosefa, LB, Honolulu (Hawaii) St. Louis School
Cary Angeline, TE, Exton (Penn.) Downington East