Santiago threw 114 pitches, 77 for strikes, and worked his way out of two jams, striking out
Santiago has 108 strikeouts and 35 walks and has held opponents to a .153 average (11 for 72) with runners in scoring position this season.
Mike Trout’s two-pitch at-bat resulted in a line-out to third base, but
The homer, which gave the Angels a 7-0 lead, was also Pujols' 1,136th extra-base hit, tying him for 12th place with Ty Cobb on the all-time list.
The Red Sox snapped a 21-inning scoreless streak to start their four-game series in Anaheim when Ortiz and
But Sandoval’s fielding error at third base paved the way for the Angels to score four unearned runs off reliever Noe Ramirez in the bottom of the fourth. Aybar hit an RBI single and
The Angels, who have won 14 of 17 games and are 10-3 in July, can complete a four-game sweep of the Red Sox with a win in the second game Monday night.
Calhoun also walked and scored in the fourth and is batting .360 (18 for 50) with five homers, five doubles and 15 runs batted in over his last 12 games. Aybar, who had two hits and two runs, is batting .435 (20 for 46) over his last 12 games and .400 (34 for 85) since June 19.