The team said Tuesday that the Pro Bowl quarterback has experienced soreness in the ankle since the end of last season and the problem isn't getting better.
"The ankle was sore after the San Francisco game and we wanted to see if rest would calm it down, but it is still bothering him and the decision was made to address it," Panthers trainer Ryan Anderson said in a news release.
The surgery will be performed by Panthers team physician Robert Anderson . If all goes as expected, Newton could return before training camp begins at the end of July.
Newton has started all 48 regular-season games since arriving as the No. 1 overall pick from Auburn in 2011.
The family of Indianapolis Colts owner Jim Irsay said that he has put himself in a treatment facility after police found multiple prescription drugs in his vehicle during a traffic stop.
The 54-year-old Irsay, who acknowledged a painkiller dependency more than a decade ago, faces preliminary charges of misdemeanor driving while intoxicated and four felony counts of possession of a controlled substance. He was arrested near his home in suburban Carme, Ind., late Sunday and released the next day.