The Penguins confirmed Crosby's diagnosis Sunday after the two-time NHL MVP was held out of the team's last two games for precautionary reasons before undergoing further testing Saturday.
The Penguins said Crosby should be past the infectious stage of the disease, but he will still miss at least one more game before being reevaluated. Earlier this year, Crosby received a booster shot against the virus before taking part in the Sochi Winter Olympic Games.
Crosby, 27, is one of several NHL players who have contracted mumps this season. Ducks teammates Corey Perry, Francois Beauchemin and Clayton Stoner each missed games because of the disease. Players on the Minnesota Wild, New Jersey Devils and New York Rangers also have been diagnosed with mumps.
Crosby ranks fourth in NHL scoring this season with nine goals and 35 points in 27 games played. Crosby finished with a league-best 104 points last season.
The Associated Press contributed to this report.