USC's Sept. 13 game at Boston College will kick off at 5 p.m. PDT, USC announced.
The game will be televised by ABC, ESPN or ESPN2.
USC defeated Boston College, 35-7, last season at the Coliseum.
USC last visited Boston College in 1988, when the Trojans won an opener, 34-7, before a crowd of 32,000.
USC, under first-year Coach Steve Sarkisian, will open training camp in early August.
The Trojans play Fresno State and at Stanford before traveling to Boston College.