Patrick walked away from the crash unhurt.
She was running 26th just past the halfway point of the Sprint Cup Series race at Phoenix International Raceway when the tire blew, sending her car into the outside wall.
The Ford of David Ragan, who was running just behind Patrick, then plowed into her car, ripping off most of the left-side bodywork of Patrick's green Chevy.
Patrick's car came to rest just past the start-finish line in front of the main grandstands, the hood wrenched back, covering Patrick's windshield.
"I took a hard hit to the right and then on the left," Patrick said. "I'm fine. We were making progress but unfortunately our day ended early."
Patrick, 30, is in her first full season in the Sprint Cup Series. She finished eighth a week ago in the season-opening Daytona 500.