First she injected them with specialized neural stem cells that naturally zero in on the tumors and surround them. Then she administered an anti-cancer agent that the cells converted into a highly toxic drug.
In her tests, 90% of the animals were rid of their tumors while healthy brain tissue remained undamaged.
To hear Aboody tell it, that was the easy part.
"People are curing mice right and left," said the City of Hope neuroscientist. The real challenge is convincing the Food and Drug Administration to let her try this on people with brain tumors.
Reams of safety data must be amassed to satisfy the FDA. Scientists struggle to navigate all that red tape. Many don't even try.
Now the California Institute for Regenerative Medicine has stepped in -- with an $18-million grant financed by state taxpayers, courtesy of 2004's Proposition 71, which created the state agency.
Aboody's windfall is just one manifestation of the agency's changing mission, galvanized by the 2008 hire of a director with a track record of moving discoveries from lab to clinic.
For 3 1/2 years, the agency focused on the basic groundwork needed to someday use human embryonic stem cells to replace body parts damaged by injury or disease. Such cures are still far in the future.
Now the institute has a more immediate goal: boosting therapies that are much further along in development and more often rely on less glamorous adult stem cells. It is concentrating its vast financial resources on projects that could cure conditions such as age-related macular degeneration, AIDS, sickle cell disease and various types of cancer.
In shifting its focus, the agency is moving to fill a void known as the "valley of death" -- a point at which projects are typically too commercial to vie for federal funds, yet too risky to entice private investors.
This is how the agency -- with its constitutional mandate to invest $3 billion in stem cell research over 10 years -- plans to stay relevant as the state slashes billions from education, public safety, health and welfare programs to close a gargantuan budget hole.
"If we went 10 years and had no clinical treatments, it would be a failure," said the institute's director, Alan Trounson, a stem cell pioneer from Australia. "We need to demonstrate that we are starting a whole new medical revolution."
Other changes helped spur this new direction. In March, President Obama said he would expand federal funding for research on embryonic stem cells beyond the narrow limits set in 2001 by President Bush, making state funding less crucial.
And since Proposition 71 was passed, scientists have created new kinds of stem cells -- known as induced pluripotent stem cells -- that can be coaxed to form many different types of tissues but are made without harming embryos and thus are eligible for federal funding.
When the institute handed out nearly $230 million in October to 14 research teams, including Aboody's at City of Hope, it was its largest scientific investment by far. But it came with strings attached: In four years, recipients should have a clinical trial request ready to file with the FDA. Only four of the projects involve embryonic stem cells.
A new emphasis
It is a significant change in direction for an effort originally designed to bolster research on human embryonic stem cells.
Proposition 71 was set in motion in August 2001, when Bush announced that federal funds could be used to study stem cell lines derived from human embryos. It marked the first time money from the National Institutes of Health and other government agencies was made available to the growing cadre of biologists who believed the cells could be transformed into replacement tissues that would cure a range of diseases.