Tamiflu: How Much Is Enough?

Confusing directions on liquid suspensions of the antiviral drug


may inadvertently cause parents to give either too little of the drug, impeding the child's recovery, or a toxic overdose, physicians warned in a letter published Wednesday in the online version of the New England Journal of Medicine.

Prescriptions for the drug are often written with doses in fractions of a teaspoon, but the dropper packaged with the drug is marked in milligrams, requiring a difficult conversion of units, said the study's lead author, Dr. Ruth Parker of the Emory University School of Medicine.

"It's an egregious error that there is a conflict in the prescription labeling instructions and the dosage device that comes in the exact same box," said co-author Dr. Michael Wolf of

Northwestern University's

Feinberg School of Medicine. "It's incredibly confusing to parents."

The conflict was found by co-author Kara Jacobson, a senior research associate at Emory's Rollins School of Public Health and mother of a 6-year-old girl who contracted


influenza, or swine flu. Their Tamiflu prescription called for three-quarters of a teaspoon twice a day.

Jacobson and her husband, an internist, had to do a


search, then solve an equation to determine the correct dose: 5 ml. (volume of a teaspoon) x .75 x 12 mg./ml. of Tamiflu = 45 mg. It took them both working together for 30 minutes to solve the equation, and they suspect that many parents would have greater difficulty doing so.

Their recommendation: If a prescription calls for teaspoons or fractions of a teaspoon, then the syringe should be marked in teaspoons.