A promising remedy against depression

Several natural remedies for depression have captured the public’s fancy in recent years, including St. John’s wort, tryptophan and SAM-e. Now, an amino acid called 5-HTP, or hydroxytryptophan, has joined their ranks. Made naturally by the body, 5-HTP is a precursor to serotonin, the neurotransmitter that is key to regulating mood. The supplement form is derived from the seed of an African plant.

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Uses: Besides its purported antidepressant effect, 5-HTP is taken for weight control because inadequate serotonin levels may be partially responsible for the desire to overeat. The supplement is used to a lesser extent for relief of pain, premenstrual syndrome and insomnia.

Dose: Typically 50 to 100 milligrams three times a day.

Precautions: Single doses of 300 milligrams or higher can cause nausea. The major concern of 5-HTP, however, is its link to a dangerous condition called eosinophilia-myalgia syndrome, a sometimes fatal disorder that causes an elevated count of white blood cells and severe muscle pain. This is the condition that affected more than 1,500 users of the amino acid L-tryptophan in the late 1980s. While 5-HTP, which is a metabolite of L-tryptophan, is generally considered safe, long-term use (six months or more) may increase the risk of eosinophilia. The supplement should not be used by people taking antidepressants.

Research: Much of the research on 5-HTP has been performed outside the United States. Although the studies suggest an antidepressant effect, larger, long-term studies are needed. There is less evidence that 5-HTP is useful for weight loss.

Dietary supplement makers are not required by the U.S. government to demonstrate that their products are safe or effective. Ask your health-care provider for advice on selecting a brand.

-- Shari Roan