| Estimated sales in the U.S. and Canada: |
| Movie (studio) | 3-day gross (millions) | Percentage change from last weekend | Total (millions) | Days in release |
|
| 1 | Avatar (Fox/Dune/Ingenious) | $30 | -14% | $594.4 | 45 |
|
| 2 | Edge of Darkness (Warner Bros./GK Films) | $17.1 | NA | $17.1 | 3 |
|
| 3 | When in Rome (Disney) | $12.1 | NA | $12.1 | 3 |
|
| 4 | Tooth Fairy (Fox/Walden) | $10 | -29% | $25.1 | 10 |
|
| 5 | The Book of Eli (Warner Bros./Alcon) | $8.8 | -44% | $74.4 | 17 |
|
| 6 | Legion (Sony Screen Gems) | $6.8 | -61% | $28.6 | 10 |
|
| 7 | The Lovely Bones (Paramount) | $4.7 | -44% | $38 | 52 |
|
| 8 | Sherlock Holmes (Warner Bros./Village Roadshow) | $4.5 | -32% | $197.6 | 38 |
|
| 9 | Alvin and the Chipmunks: The Squeakquel (Fox/New Regency) | $4 | -38% | $209.3 | 40 |
|
| 10 | It’s Complicated (Universal/Relativity) | $3.7 | -36% | $104 | 38 |