Green Goblin / Norman Osborn
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Spidey’s bad guys

Green Goblin / Norman Osborn
Wealthy businessman and scientist Norman Osborn tests his own “super soldier” military technology on himself thereby transforming into the insane Green Goblin.

“Willem Dafoe (who played Green Goblin in 2002’s Spider-man) is a fantastic actor and he’s definitely played very vulnerable characters. But he’s also played alot of villains. It was perfect Sam Raimi casting.” -- James Franco (Columbia Pictures)
Doctor Octopus / Dr. Otto Octavius
Otto Octavius is just trying to benefit mankind by creating a miniature nuclear fusion sun he manipulates with four robotic tentacles. But when he turns to crime, after running out of money trying to buy parts for a new nulear fusion device, he has to tangle with Spider-Man.

“Alfred Molina [who played Doc Ock in 2004’s “Spider-Man 2"] doesn’t normally play villains. And before [we shot “Spider-Man 3"], I wouldn’t have thought of him or Topher or myself as a villain, but when you see [Dafoe, Molina, Grace, and Church] in their roles it all makes perfect sense."--James Franco (Sony Pictures)
New Goblin / Harry Osborn
Deeply distraught about his father’s death, Harry Osborn stumbles onto his dad’s secret Green Goblin lair, and decides to build a next generation Goblin with new weapons and renewed sense of vengence.

“Harry Osborn isn’t a typical super villain, in that he’s not out for world domination or to manipulate people into following some evil plan. He simply wants to murder Spider-Man because he murdered his father. Anybody can relate to those feelings.” -- James Franco (Columbia Pictures)
Sandman / Flint Marko
On the run from the cops, petty criminal Flint Marko stumbles into a high energy particle physics test site in New Jersey. He is instantly de-molecularized into the shape-shifting Sandman.

“For Sandman we drew on wildly diverse source material - from Jewish folklore to monster movies from the 1940s. With great villains, ultimately what’s revealed, when they’re stipped of all their monster vestiges, is just these sad, regretful guys.” -- Thomas Haden Church (Columbia Pictures)
Venom / Eddie Brock
After a run-in with a tar-like alien goo from outer space, Daily Bugle photographer Eddie Brock transforms into Venom, a fanged, jaw-snapping monster.

“Venom can shoot webs, he has a spider on his chest, he has a great deal more power. Now nobody will stop him. To me, it’s a metaphor for substance abuse. The symbiote takes away Eddie’s fears.” -- Topher Grace (Columbia Pictures / Sony Pictures)