Lizzy Caplan | Showtime’s ‘Masters of Sex’
15 Images

Leading ladies of the fall TV season

Her role: Set in the 1950s Eisenhower era, the drama follows Caplan as she portrays arousal analyst Virginia Johnson. Twice-divorced and a single mom, Caplan’s character researches alongside the brilliant and curious Dr. William Masters, played by actor Michael Sheen. The pair are ultimately credited as the pioneers of human sexuality, unleashing the sexual revolution of the 1960s.

Where we’ve seen her before: Caplan played outcast and friend to Lindsay Lohan in the film “Mean Girls.” On television, she’s known for her small but recurring roles on “New Girl” and “True Blood.”  (Craig Blankenhorn / Showtime)
Her role: As Det. Amy Santiago, Fumero navigates a New York City precinct alongside a wise-cracking Andy Samberg and precinct chief Andre Braugher in this action-comedy. Her character is confident, but super-competitive, with a goal to rack up more arrests than Samberg.

Where we’ve seen her before: For four-and-a-half years, Fumero played a love-at-first-sight, smitten teen on the soap opera “One Life to Live.” Other television credits include stints on “Gossip Girl” and “CSI: NY.”  (Fox)
Her role: Set in the 16th century, the drama chronicles the rise to power of Mary Queen of Scots, played by Kane. At 15 years old, the queen travels to France and becomes engaged to Prince Francis. Her three best friends are ladies-in-waiting.

Where we’ve seen her before: Kane played a recurring role on horror TV series “Teen Wolf.” She also starred in action-adventure “Power Rangers R.P.M” and Australian TV series “Neighbours.”  (Mathieu Young / The CW)
Her role: When a Revolutionary War hero wakes up in modern-day New York, he’s confronted by local law enforcement, and then paired with Beharie’s character, feisty Lt. Abbie Mills. A novice cop, Beharie taps her own supernatural history of the city to fend off the four horsemen of the apocalypse.

Where we’ve seen her before: On the big screen, Beharie portrayed Rachel Robinson, wife of legendary baseball player Jackie Robinson, in the biopic “42.” Beharie is also known for her film debut as a single mother faced with drug charges in the drama “American Violet.”  (Kent Smith / Fox)
Her role: A spinoff of ABC’s “Once Upon a Time,” this fantasy drama is based around Lewis Carroll’s magical fairy tale “Alice’s Adventures in Wonderland.” Lowe plays young Alice who finds herself in a new land on the other side of a rabbit hole. Far-fetched characters like an invisible cat, a hookah-smoking caterpillar and moving playing cards accompany her whirlwind journey.

Where we’ve seen her before: Lowe had a small role on the comedy series “The Slap” and on the drama “Satisfaction.” In between, she starred in movie shorts like “Moth” and “Kiss.”  (Jack Rowand / ABC)
Her role: Already stirring up controversy for her role on this comedy sitcom, Song plays Veronica, the go-getter assistant of Seth Green’s character. The most buzzed about scene so far has Song dressed in a sexy Sailor Moon costume, giggling like an anime caricature with hopes to sway an Asian entrepreneur.

Where we’ve seen her before: Song played ditzy and affluent London Tipton on the Disney Channel series “The Suite Life of Zack and Cody.” She went on to star in the show’s spinoffs and Disney feature films including “College Road Trip,” alongside Raven Symone. Most recently she has appeared on episodes of “Scandal” and “New Girl.”  (Jennifer Clasen / Fox)
Her role: On the comedy series, Akerman plays a reformed party girl. She finds herself in a new family household when the man she loves comes with baggage -- three manipulative children and two disapproving ex-wives kind of baggage.

Where we’ve seen her before: In a slew of rom-coms like “27 Dresses,” “The Proposal” and “The Heartbreak Kid.” Her television credits include stints on “Entourage” and “The Comeback.”  (ABC)
Her role: Created by Joss Whedon, Jed Whedon and Maurissa Tancharoen and based on the Marvel Comics organization S.H.I.E.L.D, the series stars Wen as S.H.I.E.L.D. agent Melinda May. More of an observer than a listener, Wen’s character is a world-class pilot and weapons specialist.

Where we’ve seen her before: She voiced Mulan in the Disney animation film by the same name. She also played a physician in the medical drama “ER” for nine years and a state judge on the comedy “Two and a Half Men” for three years.

 (Justin Lubin / ABC)
Her role: Gellar is Sydney, the daughter of advertising ace Simon Roberts, played by Robin Williams. Gellar’s by-the-book character finds herself putting a damper on her father’s fun.

Where we’ve seen her before: Need we say...Gellar starred as protagonist Buffy Summers in the action-drama “Buffy the Vampire Slayer.” On the big screen, she played an American nurse living in Tokyo in horror mystery “The Grudge” and “The Grudge 2.”  (Richard Cartwright / CBS)
Her role: As esteemed surgeon Dr. Ellen Sanders, Collette finds herself tangled in a scheme days before she is set to operate on the president of the United States. A squad of kidnappers led by actor Dylan McDermott invade Collette’s home and won’t let her or beloved brood free until she accidentally on purpose kills the president.

Where we’ve seen her before: In comedies including “Enough Said,” “Little Miss Sunshine” and “Connie and Carla” and dramas including “The Way Way Back,” “Hitchcock” and “Mental.”  (Jeff Neumann / CBS)
Her role: As Christy, a newly single mother, Faris is in the midst of overcoming her alcoholism and decides to restart her life in California’s Napa Valley with her mother -- who also is an alcoholic.

Where we’ve seen her before: On the big screen, we’ve seen Faris star in “The House Bunny” with smaller roles in “The Dictator,” “Brokeback Mountain” and “Lost in Translation.”  (Monty Brinton / CBS)
Her role: Alongside, actresses Lauren Ash and Liza Lapira, Wilson plays thrill-seeking and nerdy Kimmie. The trio of friends make it their mission to have a super fun night every Friday. Wilson created the comedy and also serves as the series’ writer.

Where we’ve seen her before: In a swath of comedies like “Pitch Perfect,” “What to Expect When You’re Expecting” and “Bridesmaids.” Wilson can also be seen on comedy TV series like “Bogan Pride,” “Pizza” and “World Record Pizza.”  (Colleen Hayes / ABC)
Her role: Having been reimagined and reincarnated several times before this, the science fiction series follows a pack of teenagers hailing from all parts of the globe. With Robbie Amell and Luke Mitchell, List embodies the next stage in human evolution with powers to teleport and communicate telepathically.

Where we’ve seen her before: On the 1960s drama “Mad Men” and comedy drama “90210" in recurring roles. In addition to stints on action-comedy “Monk” and drama “One Tree Hill.”  (The CW)
Her role: Cameron plays the dual roles of identical twins on this family-friendly comedy. Liv is an uber-popular television star whose hit show has come to an end. Meanwhile, Maddie is a straight-A student and budding basketball star who finds her life changing when her sister returns to her Wisconsin high school.

Where we’ve seen her before: Cameron played small roles on the Reba McEntire comedy “Malibu Country,” crime drama “The Mentalist” opposite Simon Baker and comedy drama “Shameless” with Emmy Rossum.  (Disney)
Her role: Set 35 years into the future, this sci-fi drama follows a cluster of Los Angeles Police Department cops who pair up with life-like androids “to protect and serve.” Taylor plays Capt. Sandra Maldonado, a solid role originally intended for a man.

Where we’ve seen her before: On TV series like “State of Mind,” “Six Feet Under” and “Deadline.” On big screen flicks like “Ransom,” “High Fidelity” and “The Conjuring.”  (FOX)