The Lakers lost their fourth consecutive game, falling to the Hornets in Charlotte, 108-98, on Monday night.
Hornets guard Kemba Walker had a huge night, leading all scorers with 38 points in 42 minutes.
After the Hornets pulled ahead early by seven, the Lakers kept the game competitive until late in the fourth, with Walker pouring in 18 points in the quarter.
The Lakers managed only 17 points in the fourth quarter, getting outscored by 10 points in the second half.
Kobe Bryant led the Lakers with 20 points, but he missed 15 of 20 shots, taking 12 from three-point range and converting only three. Brandon Bass scored 12 points off the bench on a perfect five for five from the field.
Larry Nance Jr. also scored 12 points on six-for-seven shooting while Lou Williams, Julius Randle and Nick Young each added 11.
The Lakers shot 41.2% from the field, 31% (nine for 29) from three-point range and 82.6% (19 for 23) from the free-throw line.
The Hornets shot 48.3%, 24% (six for 25) and 72.7% (16 for 22), respectively. Nicolas Batum finished with 15 points, 11 assists and five rebounds.
Charlotte also got 16 points from Cory Zeller and 13 from both P.J. Hairston and Jeremy Lin.
The Lakers (5-27) next travel to Boston to play the Celtics (18-13) on Wednesday. The Hornets (17-13) host the Clippers (19-13) on Wednesday.