UPDATE: Crews rescue 50 motorists trapped overnight on San Bernardino mountain road
"Everyone is OK," Martinez said. "But we need to get those people out of there as quickly as we can."
Nearly all of State Route 38 -- from Forest Falls Boulevard in Forest Falls to Big Bear Dam -- was closed as vehicles became stranded in the snow.
The cold storm from Canada has brought heavy winds and several inches of snow across Southern California.
The National Weather Service forecast snow across the region to as low as 2,000 feet above sea level. The Antelope Valley and San Gabriel Mountains were expected to see a dusting, while higher elevations in Los Angeles County were expected to see up to 5 inches.
Strong winds were reported from Ventura down to the southern reaches of Orange County. Fremont Canyon in Orange County saw winds up to 57 mph, while Malibu Hills saw gusts up to 70 mph.
National Weather Service meteorologist Greg Martin said the strong winds would continue through Wednesday morning but drop off in the late afternoon.
The snow and light rain are expected to move out by late Wednesday.
"When things clear out, it should get colder," Martin said.