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‘Research Offers . . . Great Promise and Great Peril’

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From Associated Press

Excerpts from President Bush’s announcement Thursday that he will allow federal funding for research on existing stem cell lines:

Many people are finding that the more they know about stem cell research, the less certain they are about the right ethical and moral conclusions.

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A large number of these embryos already exist. They are the product of a process called in vitro fertilization, which helps so many couples conceive children. When doctors match sperm and egg to create life outside the womb, they usually produce more embryos than are implanted in the mother.

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Once a couple successfully has children, or if they are unsuccessful, the additional embryos remain frozen in laboratories. Some will not survive during long storage; others are destroyed. A number have been donated to science and used to create privately funded stem cell lines. And a few have been implanted in an adoptive mother, and born, and are today healthy children.

Based on preliminary work that has been privately funded, scientists believe further research using stem cells offers great promise that could help improve the lives of those who suffer from many terrible diseases, from juvenile diabetes to Alzheimer’s, from Parkinson’s to spinal cord injuries. And while scientists admit they are not yet certain, they believe stem cells derived from embryos have unique potential.

You should also know that stem cells can be derived from sources other than embryos: from adult cells, from umbilical cords that are discarded after babies are born, from human placentas. And many scientists feel research on these types of stem cells is also promising.

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Research on embryonic stem cells raises profound ethical questions, because extracting the stem cell destroys the embryo and thus destroys its potential for life.

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As I thought through this issue, I kept returning to two fundamental questions. First, are these frozen embryos human life and therefore something precious to be protected? And second, if they’re going to be destroyed anyway, shouldn’t they be used for a greater good, for research that has the potential to save and improve other lives?

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On the first issue, are these embryos human life? Well, one researcher told me he believes this 5-day-old cluster of cells is not an embryo, not yet an individual, but a pre-embryo. He argued that it has the potential for life, but it is not a life because it cannot develop on its own.

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An ethicist dismissed that as a callous attempt at rationalization. “Make no mistake,” he told me, “that cluster of cells is the same way you and I, and all the rest of us, started our lives. One goes with a heavy heart if we use these,” he said, “because we are dealing with the seeds of the next generation.”

And to the other crucial question--If these are going to be destroyed anyway, why not use them for good purpose?--I also found different answers.

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Many of these embryos are byproducts of a process that helps create life, and we should allow couples to donate them to science so they can be used for good purpose instead of wasting their potential.

Others will argue there is no such thing as excess life, and the fact that a living being is going to die does not justify experimenting on it or exploiting it as a natural resource.

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Embryonic stem cell research is at the leading edge of a series of moral hazards. The initial stem cell researcher was at first reluctant to begin his research, fearing it might be used for human cloning. Scientists have already cloned a sheep. Researchers are telling us the next step could be to clone human beings to create individual designer stem cells, essentially to grow another you, to be available in case you need another heart or lung or liver.

I strongly oppose human cloning, as do most Americans. We recoil at the idea of growing human beings for spare body parts or creating life for our convenience.

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Eight years ago, scientists believed fetal tissue research offered great hope for cures and treatments, yet the progress to date has not lived up to its initial expectations. Embryonic stem cell research offers both great promise and great peril, so I have decided we must proceed with great care.

As a result of private research, more than 60 genetically diverse stem cell lines already exist. They were created from embryos that have already been destroyed, and they have the ability to regenerate themselves indefinitely, creating ongoing opportunities for research.

I have concluded that we should allow federal funds to be used for research on these existing stem cell lines, where the life-and-death decision has already been made.

Leading scientists tell me research on these 60 lines has great promise that could lead to breakthrough therapies and cures. This allows us to explore the promise and potential of stem cell research without crossing a fundamental moral line by providing taxpayer funding that would sanction or encourage further destruction of human embryos that have at least the potential for life.

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