Lobelia may cause seizures and tremors

The active ingredient in Lobelia inflata is a nitrogen-containing compound called lobeline, which acts like nicotine in the body. The Cherokee’s propensity for smoking the violet-flowered plant gave it the nickname Indian tobacco. Lobelia acquired its other nickname, pukeweed, when 19th century physicians prescribed it to induce vomiting in their patients. L. inflata is the species used in most herbal supplements today.

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Uses: Lobelia inflata is used to treat asthma, respiratory infections and depression. It’s also prescribed in efforts to quit smoking. Species once widely used by Native Americans include L. syphilitica for syphilis and L. cardinalis for worms, fever and body aches.

Dose: Lobelia supplements are sold as liquid or capsules containing dried herb. Doses vary, but in general liquid preparations are recommended over the bitter-tasting dry herb. Take no more than a few dozen grams of lobelia per day.

Precautions: Lobelia -- especially at doses of several hundred milligrams a day or more -- can cause heavy perspiration, coughing, nausea, vomiting, tremors and seizures. Pregnant and nursing women should avoid the herb as it can pass into breast milk.

Research: Human studies investigating lobelia’s effectiveness in smoking cessation have failed to produce good evidence that the herb works. Animal studies show that lobelia opens airways in the lungs and thins out mucus. Studies also hint that the herb can increase levels of the pleasure-causing chemical dopamine in the brain and may combat depression.

Dietary supplement makers are not required by the U.S. government to demonstrate that their products are safe or effective. Ask your healthcare provider for advice on selecting a brand.

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-- Elena Conis