Former President Luis Echeverria was charged in connection with a 1968 massacre by soldiers and police at a student rally in Mexico City.
Echeverria, interior minister at the time, and seven others face charges of genocide and kidnapping. Officials said about 30 people were killed, but witnesses put the toll as high as 300.
A judge will rule as early as today on whether to issue arrest orders. In July, a judge found insufficient evidence of genocide when similar charges were filed.