A small number of children in California have come down with
The afflicted kids suffer severe weakness or paralysis, which strikes rapidly -- sometimes after a mild respiratory illness. Scans of the patients' spinal cords show patterns of damage similar to that found in polio sufferers, Glaser said. Two of the affected children tested positive for
Dr. Keith Van Haren, a pediatric neurologist at Stanford University's Lucile Packard Children's Hospital who has worked with Glaser's team, will present the cases of five of the children at the American Academy of Neurology's upcoming annual meeting in Philadelphia.
All five patients had paralysis in one or more arms or legs that reached its full severity within two days, he said. None had recovered limb function after six months.
"We know definitively that it isn't polio," Van Haren added, noting that all had been vaccinated against that disease.
State health investigators have been tracking the new California cases closely since a physician first requested polio testing for a child with severe paralytic illness in the fall of 2012, Glaser said. She called that request "concerning," because polio has been eradicated in the U.S., and the patient had not traveled abroad.
In the year that followed, Glaser's team continued to hear about additional children with symptoms that could not be chalked up to known causes like
Berkeley resident Sofia Jarvis, 4, is one of Van Haren's patients. The girl suffered paralysis in her left arm following a brief
"She went to grab a toy, and mid-grasp her arm stopped working," said mother Jessica Tomei.
Sofia did not test positive for an enterovirus, Tomei said. Her two older brothers have no signs of illness.
Glaser said that it was possible that children who tested negative still may have contracted their illnesses from viruses that couldn't be detected because test samples were "not optimal." She urged doctors to report new cases of acute paralysis so that investigators can attempt to figure out a possible cause.
"We want to hear from local public health jurisdictions and physicians who are seeing similar illnesses," she said.
Van Haren said that most people who are infected by polio or viruses like it never develop symptoms, with only 1% developing neurologic complications like paralysis. Scientists do not know why certain people are affected so severely.