Starting rookie Anthony Brown in place of Bryant and Nick Young for Clarkson, the Lakers shot only 34.1% from the field, 18.5% (5 of 27) from three-point range and 70% (14 of 20) from the free-throw line.
Atlanta shot 54.4%, 46.4% (13 of 28) and 73.1% (19 of 26), respectively. Dennis Schroder led the Hawks with 16 points off the bench. Kyle Korver added 15, Kris Humphries 14, Jeff Teague 12, Paul Millsap 11 and Kent Bazemore 10.
Lakers forward Julius Randle reached a double-double with 16 points and 10 rebounds, on a respectable seven of 14 shooting.
D'Angelo Russell struggled, scoring only seven points while missing 13 of 16 shots. The Lakers' rookie guard dished five assists but had five turnovers.
The only other Lakers in double figures were reserves Brandon Bass with 12 points and Marcelo Huertas with 10. Young managed just five points, missing eight of nine shots.
The Lakers (12-51) play again on Sunday, hosting the Golden State Warriors (55-5). The Hawks (34-28) stay in Los Angeles to play the Clippers (40-20) on Saturday.