First Nationwide is planning a big mortgage sale.

Anthony M. Frank, chairman of the San Francisco-based savings and loan company, said the firm will package and sell more than $2 billion in fixed-rate home mortgages. The transaction, which is expected to be completed by the end of the year, coincides with Ford Motor’s $493-million acquisition of First Nationwide. The mortgage sale will be the largest of its kind to date, Frank said. Proceeds will be used to retire debt and buy short-term auto loans written by the auto maker’s financing arm, Ford Credit.