Mexico's top anti-drug chief said Tuesday that police had captured Luis and Jesus Amezcua, two of the country's most wanted drug traffickers.
"Theirs is the fourth most important organization dedicated to the trafficking of illegal substances in Mexico," the country's special anti-narcotics prosecutor Mariano Herran Salvatti told a news conference.
The two brothers, heads of Mexico's Colima cartel and known as the kings of methamphetamine, were arrested on charges of money laundering and criminal association, Herran said.
Operating out of the western Mexican city of Guadalajara, the two men are also wanted in the U.S. on drug trafficking charges.
In November, Mexico seized their brother Adan Amezcua.
Mexico was recertified by Washington this year as an ally in the anti-narcotics fight but has been severely criticized by some members of Congress for not doing enough.
An estimated two-thirds of Colombian cocaine smuggled into the U.S. passes through Mexico.