| Estimated sales in the U.S. and Canada: |
| Movie (studio) | 3-day gross (millions) | Percentage change from last weekend | Total (millions) | Days in release |
|
| 1 | Avatar (Fox/Dune/Ingenious) | $36.0 | -16% | $552.8 | 38 |
|
| 2 | Legion (Sony Screen Gems) | $18.2 | NA | $18.2 | 3 |
|
| 3 | The Book of Eli (Warner Bros./Alcon) | $17.0 | -48% | $62.0 | 10 |
|
| 4 | Tooth Fairy (Fox/Walden) | $14.5 | NA | $14.5 | 3 |
|
| 5 | The Lovely Bones (Paramount) | $8.8 | -48% | $31.6 | 45 |
|
| 6 | Sherlock Holmes (Warner Bros./Village Roadshow) | $7.1 | -28% | $191.6 | 31 |
|
| 7 | Extraordinary Measures (CBS) | $7.0 | NA | $7.0 | 3 |
|
| 8 | Alvin and the Chipmunks: The Squeakquel (Fox/New Regency) | $6.5 | -44% | $204.2 | 33 |
|
| 9 | It’s Complicated (Universal/Relativity) | $6.2 | -24% | $98.6 | 31 |
|
| 10 | The Spy Next Door (Lionsgate/Relativity) | $4.8 | -51% | $18.7 | 10 |