Heart inflammation after virus is rare in Big Ten athletes

College football players wait for the snap on the line of scrimmage during practice.
College football players wait for the snap on the line of scrimmage during practice. A study of Big Ten Conference athletes who have had COVID-19 found that heart inflammation was rare and in most cases caused no obvious symptoms.
(Ted S. Warren / Associated Press)

Heart inflammation is rare in Big Ten Conference athletes who’ve had COVID-19 and in most cases causes no obvious symptoms, according to the first data published from a league registry.

The results from the Big Ten COVID-19 Cardiac Registry show just 37 of nearly 1,600 athletes — a little over 2% — had evidence of heart inflammation on imaging tests. Of these, nine athletes had chest pain, palpitations or other symptoms, according to the study, published Thursday in JAMA Cardiology.

Follow-up testing showed inflammation had disappeared a month later in most of the athletes affected, but about 40% of the 37 had scarring. The researchers said it is uncertain whether these effects pose a substantial health risk, although myocarditis, the medical term for the type of heart inflammation involved, is a leading cause of sudden death in athletes.


Heart inflammation has been found in other COVID-19 patients, and concern that the virus could increase risks for athletes led the league to create the registry last September.

That same month, the Big Ten mandated heart screening including imaging tests for athletes with positive COVID-19 tests, before allowing them to return to play. Through Dec. 15, 9,255 athletes had been tested and 2,810, or 30%, had tested positive.

The study involved 2,461 athletes from 13 Big Ten schools who had heart testing, including 1,597 whose testing included imaging scans, from March through Dec. 15, 2020. It is not known if the inflammation found was caused by COVID-19 or something else.

Most of those whose scans showed inflammation were men. Age and race data were not included.

The yearly incidence of sudden cardiac death in college athletes has been estimated at 1 in 50,000.

A study published in JAMA Cardiology suggests that heart inflammation is uncommon in pro athletes who’ve had mild COVID-19 and most don’t need to be sidelined.

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“Even a small number of events in a young and apparently healthy population has devastating consequences,” the study authors said.


Dr. Saurabh Rajpal, a cardiologist at Ohio State University and study coauthor, said the composite results echo other studies, including one at his university. But he noted that the new data found wide variation in prevalence of affected athletes, from zero at one university to 7% at another.

Different imaging scanners and techniques may explain the variations, Rajpal said, adding that the results underscore a need to develop a standard protocol for heart testing in athletes.

Athletes who develop heart inflammation should be sidelined until symptoms disappear and imaging scans are normal, he said.

Those with COVID-19 want to know “how long until we can go back and start playing? We mostly just make up a number,” Rajpal said. “As we follow more patients, we will be able to come up with an answer.”

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The authors emphasize that the imaging scans detected more heart inflammation than other less expensive tests, and found it in some athletes who had normal results on those other tests.

But a JAMA Cardiology editorial questioned whether imaging should be required for deciding when athletes at the college and high school levels can return to play.

Since it remains unknown whether inflammation found on the scans poses a potential risk for sudden death, relying on blood tests and other more widely available methods should be considered, the editorial suggests.

Athletes, their families, coaches and other stakeholders should be aware that imaging may pick up a few more cases of inflammation, but also might lead to unnecessary restrictions on returning to play, the editorial says.