| Estimated sales in the U.S. and Canada: |
| Movie (studio) | 3-day gross (millions) | Percentage change from last weekend | Total (millions) | Days in release |
|
| 1 | Avatar (Fox/Dune/Ingenious) | $48.5 | -29% | $429.0 | 24 |
|
| 2 | Sherlock Holmes (Warner Bros./Village Roadshow) | $16.6 | -55% | $165.2 | 17 |
|
| 3 | Alvin and the Chipmunks: The Squeakquel (Fox/New Regency) | $16.3 | -54% | $178.2 | 19 |
|
| 4 | Daybreakers (Lionsgate) | $15.0 | NA | $15.0 | 3 |
|
| 5 | It’s Complicated (Universal/Relativity) | $11.0 | -41% | $76.4 | 17 |
|
| 6 | Leap Year (Universal/Relativity) | $9.2 | NA | $9.2 | 3 |
|
| 7 | The Blind Side (Warner Bros./Alcon) | $7.8 | -35% | $219.2 | 52 |
|
| 8 | Up in the Air (Paramount/Montecito) | $7.1 | -34% | $54.7 | 38 |
|
| 9 | Youth in Revolt (Weinstein Co.) | $7.0 | NA | $7.0 | 3 |
|
| 10 | The Princess and the Frog (Disney) | $4.7 | -52% | $92.6 | 47 |