Christina Applegate reveals she has multiple sclerosis, calls it a ‘tough road’

A blond woman posing in an off-shoulder black dress
Actor Christina Applegate arrives at the 2020 Critics’ Choice Awards in Santa Monica.
(Jordan Strauss / Invision/Associated Press)

Emmy Award winner Christina Applegate has announced that she has multiple sclerosis, describing her diagnosis as a “tough road.”

The 49-year-old actor, known for her roles in “Married... With Children” and “Dead to Me,” said in a tweet late Monday that she was diagnosed “a few months ago.”

“It’s been a strange journey. But I have been so supported by people that I know who also have this condition,” wrote Applegate. “It’s been a tough road. But as we all know, the road keeps going.” She added in a later post: “Now I ask for privacy. As I go through this thing.”


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Multiple sclerosis — also known as MS — affects the nervous system and often results in progressive physical and cognitive decline.

More than 2.3 million people have a diagnosis of MS worldwide, according to the National Multiple Sclerosis Society. Nearly 1 million people over the age of 18 live with a diagnosis of MS in the U.S., the nonprofit organization adds.

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Applegate won her Emmy in 2003 for a guest spot on “Friends” and has a Tony Award nomination for the musical “Sweet Charity.” Her films include “The Sweetest Thing,” “Anchorman,” “Hall Pass” and “Bad Moms.”

She has previously discussed her 2008 battle with breast cancer, after which she had a double mastectomy as well as her ovaries and fallopian tubes removed.


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