After losing earlier in the year to the Lakers at Staples Center, the Pistons demolished the Lakers on Sunday in Detroit, 111-91.
Kobe Bryant tried to play through an upset stomach, but struggled to score five points in 25 1/2 minutes, shooting just two for 15 from the field.
Detroit rode the hot hands of Kentavious Caldwell-Pope (22 points) and Reggie Jackson (20), while Andre Drummond scored 18 points with 15 rebounds.
The Pistons scored the first 15 points of the game, before rookie D'Angelo Russell hit a pair of free throws to finally put the Lakers on the board.
The Lakers responded with nine in a row, to close within six, but the Pistons finished the first quarter up 13 points and never looked back.
Lou Williams was the Lakers' leading scorer with 21 points off the bench. Julius Randle notched a double-double with 15 points and 11 rebounds. Russell scored 12, as the team shot 40.0% from the field, 27.8% (five for 18) from three-point range and 75.9% from the line (22 for 29).
The Pistons shot 44.1%, 37.5% (nine for 24) and 76.9% (20 for 26), respectively.
Nick Young was ejected from the game after going scoreless in 7 1/2 minutes. Young was fouled cleanly by Pistons forward Anthony Tolliver, but Young retaliated with a hard shove.
Seldom-used players Ryan Kelly, Marcelo Huertas and Robert Sacre got some court time, playing 12 minutes apiece. Huertas scored eight points with four assists.
The Pistons, who have won four straight, were never in danger of losing their lead over the Lakers.
The Lakers (3-17) will travel to Toronto to play the Raptors (12-9) on Monday. The Pistons (12-9) also play Monday, visiting the Charlotte Hornets (11-8).