USC vs. Arizona State: Betting odds, lines, picks against spread

USC wide receiver Jordan Addison runs a route during a win over Fresno State on Sept. 17.
USC wide receiver Jordan Addison runs a route during a win over Fresno State on Sept. 17. The Trojans are the big favorite in Saturday’s matchup with Arizona State.
(Mark J. Terrill / Associated Press)

The USC Trojans take their No. 6 AP ranking into their 7:30 p.m. Saturday meeting with the Arizona State Sun Devils at the Coliseum.

The Trojans are off to a 4-0 start under first-year coach Lincoln Riley and the only Pac-12 team at 2-0 in conference play. ASU isn’t expected to threaten that perfect record as USC opened as a 24-point home favorite and that hasn’t deterred early bettors from laying the huge spread as the line is up to USC -25.5. In fact, 72% of the bets and 91% of the money (which is usually an indication of action from sharper bettors) are on the Trojans. For the most up-to-date betting trends from DraftKings, see VSiN’s college football betting splits page.

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The Trojans are led by quarterback Caleb Williams, who also came with Riley from Oklahoma. He wasn’t as sharp in last Saturday’s win at Oregon State, but rallied USC to a hard-fought 17-14 victory in the type of early-season game that fans have seen the Trojans lose in recent years. Williams is still 6-1 in the Heisman Trophy race behind Ohio State’s CJ Stroud (odds of 6-5) and Alabama’s Bryce Young (4-1).

The Arizona State program, which was already in disarray as it entered the season facing alleged recruiting violations, is off to a 1-3 start that includes coach Herman Edwards and the administration parting ways after the Sun Devils’ embarrassing 30-21 loss vs. Eastern Michigan as 20½-point home favorites.

The over/under for Saturday night’s game is set at 60½ points with USC expected to account for most of those points. Bettors don’t seem to be scared off as 55% of the bets and 74% of the money has been bet on the over.

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