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Expect more worrisome variants after Omicron, scientists warn

People wait in line at a COVID-19 testing site in New York City's Times Square.
People wait in line at a COVID-19 testing site in New York City’s Times Square. Scientists are warning that Omicron’s lightning-fast spread across the globe practically ensures it won’t be the last worrisome coronavirus variant.
(Seth Wenig / Associated Press)

Get ready to learn more Greek letters.

Why? Because scientists warn Omicron’s whirlwind advance practically ensures it won’t be the last version of the coronavirus to worry the world.

Every infection provides a chance for the virus to mutate, and Omicron has an edge over its predecessors: It spreads much faster despite emerging on a planet with more immunity from vaccines and prior illness.

More spread means more people in whom the virus can further evolve. Experts don’t know what the next variants will look like or how they might shape the pandemic, but they say there’s no guarantee the sequels of Omicron will cause milder illness or that existing vaccines will work against them.

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They urge wider vaccination now, while today’s shots still work.

“The faster Omicron spreads, the more opportunities there are for mutation, potentially leading to more variants,” said Leonardo Martinez, an infectious disease epidemiologist at Boston University.

Since it emerged in mid-November, Omicron has raced across the globe like fire through dry grass. Research shows the variant is at least twice as contagious as Delta and at least four times as contagious as the original version of the virus.

Early research points to mutations in the spike protein. But much remains unknown or unconfirmed.

Omicron is more likely than Delta to reinfect individuals who previously had COVID-19 and to cause “breakthrough infections” in vaccinated people while also attacking the unvaccinated. The World Health Organization reported a record 15 million new COVID-19 cases for the week of Jan. 3-9, a 55% increase from the previous week.

Along with keeping comparatively healthy people out of work and school, the ease with which the variant spreads increases the odds that the virus will infect and linger inside people with weakened immune systems — giving it more time to develop potent mutations.

“It’s the longer, persistent infections that seem to be the most likely breeding grounds for new variants,” said Dr. Stuart Campbell Ray, an infectious disease expert at Johns Hopkins University. “It’s only when you have very widespread infection that you’re going to provide the opportunity for that to occur.”

The Omicron variant was probably incubated in a person with poorly controlled HIV who struggled to clear a coronavirus infection.

Because Omicron appears to cause less severe disease than Delta, its behavior has kindled hope that it could be the start of a trend that eventually makes the virus milder, like a common cold.

That’s a distinct possibility, experts say, given that viruses don’t spread well if they kill their hosts very quickly. But viruses don’t always become less deadly over time.

A variant could also achieve its main goal — replicating — if infected people developed mild symptoms initially, spread the virus by interacting with others, then got very sick later, Ray explained by way of example.

“People have wondered whether the virus will evolve to mildness. But there’s no particular reason for it to do so,” he said. “I don’t think we can be confident that the virus will become less lethal over time.”

Unleashing a fast-spreading coronavirus variant on a half-vaccinated population can lead to a vaccine-resistant strain.

Getting progressively better at evading immunity helps a virus to survive over the long term. When SARS-CoV-2 first struck, no one was immune. But infections and vaccines have conferred at least some immunity to much of the world, so the virus must adapt.

There are many possible avenues for evolution. Animals could potentially incubate and unleash new variants. Pet dogs and cats, deer and farm-raised mink are only a few of the animals vulnerable to the virus, which can potentially mutate within them and leap back to people.

Another potential route: With both Omicron and Delta circulating, people may get double infections that could spawn what Ray calls “Frankenvariants” — hybrids with characteristics of both types.

When new variants do develop, scientists say it’s still very difficult to predict based on genetic features which ones might take off. For example, Omicron has many more mutations than previous variants, including around 30 in the spike protein that lets it attach to human cells. But the so-called IHU variant identified in France and being monitored by the WHO has 46 mutations and doesn’t seem to have spread much at all.

To curb the emergence of variants, scientists emphasize continuing with public health measures such as masking and getting vaccinated. While Omicron is better able to evade immunity than Delta, experts said, vaccines still offer protection and booster shots greatly reduce serious illness, hospitalizations and deaths.

Ray likened vaccines to armor for humanity that greatly hinders viral spread even if it doesn’t completely stop it. For a virus that spreads exponentially, he said, “anything that curbs transmission can have a great effect.” Also, when vaccinated people get sick, Ray said their illness is usually milder and clears more quickly, leaving less time to spawn dangerous variants.

The Biden administration is boosting efforts to identify and track coronavirus variants to help scientists see where the pandemic is heading next.

Experts say the virus won’t become endemic like the flu as long as global vaccination rates are so low. During a recent news conference, WHO Director-General Tedros Adhanom Ghebreyesus said that protecting people from future variants — including those that may be fully resistant to today’s shots — depends on ending global vaccine inequity.

Tedros said he’d like to see 70% of people in every country vaccinated by midyear. Currently, there are dozens of countries where less than a quarter of the population is fully vaccinated, according to Johns Hopkins University statistics. And in the United States, many people continue to resist available vaccines.

“These huge unvaccinated swaths in the U.S., Africa, Asia, Latin America and elsewhere are basically variant factories,” said Dr. Prabhat Jha of the Center for Global Health Research at St. Michael’s Hospital in Toronto. “It’s been a colossal failure in global leadership that we have not been able to do this.”

In the meantime, new variants are inevitable, said Louis Mansky, director of the Institute for Molecular Virology at the University of Minnesota.

With so many unvaccinated people, he said, “the virus is still kind of in control of what’s going on.”


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