Pitt, his parents, sons Pax and Maddox and daughter Shiloh represented the ailing director at the "Unbroken" premiere on Monday while she took the night off to deal with a bout of chicken pox -- a revelation the 39-year-old made in a video posted Friday ahead of the promotional tour for the World War II drama.
"I just wanted to be clear and honest about why I will be missing the 'Unbroken' events in the next few days," she explained, adding that she'd be "home, itching, and missing everyone."
"Her spirits are high," Pitt told E! News' Marc Malkin on the red carpet. "A little spotted and a little itchy, but her spirits are high."
FOR THE RECORD
Dec. 17, 10:50 a.m.: An earlier version of this post stated that Kirsten Dunst was Jack O'Connell's girlfriend. She is dating Garrett Hedlund.
On Sunday, Pitt also appeared at the Deakins Image Exhibition in Hollywood to promote the film for his longtime love, whom he wed in August.
"Unbroken," Jolie's second directorial effort, opens on Christmas Day.