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Karen N. Horn, who has been president of the Federal Reserve Bank of Cleveland since May, 1982, will resign in April to become chairman and chief executive of Bank One of Cleveland.

Horn, 43, was the first woman to be president of a Federal Reserve bank. She will become one of the two or three top woman banking executives in the nation in her new job, said John Russell, a spokesman for Banc One Corp., the Columbus-based bank holding company that owns Bank One of Cleveland.

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